Genetic predisposition to elevated LDL-C associated with narrowing of the aortic valve

(The JAMA Network Journals) In an analysis that included approximately 35,000 participants, genetic predisposition to elevated low-density lipoprotein cholesterol was associated with aortic valve calcium and narrowing of the aortic valve, findings that support a causal association between low-density lipoprotein cholesterol and aortic valve disease, according to a study appearing in JAMA. The study is being released to coincide with its presentation at the Canadian Cardiovascular Congress.